Endocrine Abstracts

An interest in art and antiques and a chance discovery in Hong Kong in 2000 led rapidly to an obsession with carvings from Northern China’s 5000 year old Hongshan Culture. The most controversial are in a unique silica glass (‘shui jing’), with a very high melting temperature (>1600 °C) and no additives or stabilisers, that could only have originated from a large unique meteorite impact. This paper will present results on the carvings of light microscopy...

Introduction: Hypogonadism is prevalent in older men and associated with various comorbidities. Despite this, it is underdiagnosed and undertreated.Aim: To identify factors associated with underdiagnosis and undertreatment of male hypogonadism.Methods: Quantitative, questionnaire-based, online survey conducted in the UK among men aged ≧40 years with hypogonadism confirmed by blood test (n=101, from N=3 871 ...

Introduction: Motor skill proficiency has shown to be a key predictor of children’s engagement and enjoyment of regular physical activity. Recent evidence suggests that obese children have increased difficulties in the planning, initiation and control of motor skills compared to their normal weighted peers (D’Hondt et al. 2009, Gentier et al. 2013). These difficulties often manifest themselves as slower or less efficient performance of motor skills....

Professor David RayDavid Ray graduated in Medicine from University of Manchester in 1987. He trained in medicine and endocrinology in the North West, before doing a PhD with Anne White and Julian Davis, again in Manchester. Towards the end of his PhD he was offered a post with Shlomo Melmed at UCLA, and, attracted by the lab, and the adjacent coast, headed west. This research post stimulated an ...

Adrenal incidentalomas (AI) are incidentally discovered adrenal masses on imaging studies requested for reasons unrelated to adrenal pathology with a prevalence of 8% in autopsy and 4% in radiologic series. Although most AI are non-functioning benign adenomas, their increasing prevalence presents diagnostic and therapeutic challenges. We report a case of adrenocortical carcinoma (ACC) in an asymptomatic 83-year-old man, 8 years after being diagnosed with AI. ACC is an uncommon...

Introduction: We describe a patient with Fibrodysplasia ossificans progressiva (FOP) who developed an osteomyelitic neuropathic toe ulcer. This was treated effectively with conservative measures, but highlighted the need for multiprofessional working in managing patients with FOP.Case: The patient’s toe ulcer occurred in 2017 and was initially managed by community podiatry and orthopaedics. The patient received multiple courses of antibiotics for r...

Introduction: Epidemiological evidence suggests that a poor diet during pregnancy leads to offspring with higher risk of chronic diseases in adulthood. Our previous work in sheep showed that mild protein-energy malnutrition in early gestation results in decreased insulin signalling in the liver, and changes in vascular endothelial growth factor (VEGF) in the kidney. The current study explored whether these changes are generalised phenomena, or organ-specific.<p class="abst...

Background: The nursing management of DKA in children is labor intensive. The traditional management of DKA involves numerous physician ordered changes of parenteral fluids. This is time consuming for the nurse; challenging for the pharmacy and can lead to delays in proper fluid administration.Aims: The purpose of this pilot study was to investigate whether a streamlined process using a three-bag-system for treating children with DKA would improve effici...

Primary pigmented nodular adrenocortical disease (PPNAD) is a rare cause of ACTH independent adrenal Cushing’s syndrome. A 32-year-old female with atrial myxomas was found to have Carney’s complex (PRKAR1A mutation negative). Screening showed biochemical Cushing’s syndrome (24 h urine free cortisol 918 nmol – nr 100–400) and the characteristic paradoxical increase in UFC during the 48 h dexamethasone suppression test was confirmed: 24 h UFC pre-dex 340...

We present the case of a 72-year-old gentleman was admitted to our hospital with atrial fibrillation secondary to severe hypokalemia of 1.8 mmol/l, but normal serum sodium and creatinine. He had prostate cancer with extensive liver and bone metastases. After potassium supplementation 180–200 mmol/day for 10 days serum levels persisted between 2.3 and 2.9 mmol/l. During this short period he developed early Cushingoid features, jaundice and diabetes. After overnignt dexamet...